Diabetes

In the US, the estimated number of people over 18 years of age with diagnosed and undiagnosed diabetes is 30.2 million.  Without ongoing, careful management, diabetes can lead to a buildup of sugars in the blood, which can increase the risk of dangerous complications, including stroke and heart disease.

SERVICES

Biomarkers

Prediabetes Biomarkers

  • ›FPG 100mg/dL (5.6mmol/L) to 125 mg/dL (6.9mmol/L) IFG›
  • ›2-h during PG during 75-g OGTT 140mg/dL (7.8mmol/L) to 199mg/dL (11.0mmol/L) (IGT)
  • ›A1C 5.7-6.4% (39-47 mmol/mol)

Predictive Biomarkers

  • glycosylated hemoglobin (HbA1c), fasting plasma glucose (FGP) levels, oral glucose tolerance test (OGTT)
  • salivary biomarkers (α2- macroglobulin, melatonin, α-hydroxybutyrate, glucose) and HbA1c
  • cardiovascular biomarkers, (high sensitivity troponin (hs-trop) and B- natriuretic peptide (BNP)
  • polymorphisms in particular genes (e.g. PPARG, KCNJ11, TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A)

Monitoring Progression

Glycemic Control

  • measuring A1c at a minimum of twice yearly for patients meeting treatment goals and
  • at least quarterly in patients not meeting goals or with changes in therapy.

Detect Chronic Kidney Disease (CKD) 

  • estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2
  • urinary albumin-to-creatinine ratio (UACR) <10 mg/g

Cardiovascular Risk Stratification

  • Glycemic Metrics (A1c)
  • Renal Biomarkers (eGFR, UACR)
  • Cardiac Biomarkers (increased concentrations of natriuretic peptides and CRP, decreased concentrations of circulating troponin)

Our approach

is a carefully validated, clinically realistic model for early diabetes mellitus screening and managing of the disease.

 

Our mathematical & computational tools

enable researchers and decision makers to make better informed decisions.