Chronic traumatic encephalopathy (CTE)

CTE is a neuropathologic condition that has been described in individuals who have been exposed to repetitive head impacts.




CTE cannot currently be diagnosed during life. Clinical symptoms can develop after a latency phase following the injuries and are not specific. Making differential diagnosis based solely on clinical features difficult. CTE can occur with comorbid pathologies (AD, PD, ALS).  CTE and aging-related dementias involve similar changes in aggregation prone molecules.


  • Risk factor for development of chronic neurodegenerative disorders later in life.
  • Prolonged secondary injury cascades after CTE can result in chronic neurodegeneration


Biomarker canditates

  • CSF: tau, Aβ42, Αβ42/40 ratio, TDP43, NFL, T-tau, GFAP, STREM2, CSF/serum alburmin ratio
  • Plasma: tau, Aβ42, Αβ42/40 ratio, NFL, T-tau, GFAP

Our approach

is a carefully validated, clinically realistic model for early diabetes mellitus screening and managing of the disease.


Our mathematical & computational tools

enable researchers and decision makers to make better informed decisions.