Chronic traumatic encephalopathy (CTE)
CTE is a neuropathologic condition that has been described in individuals who have been exposed to repetitive head impacts.
CTE cannot currently be diagnosed during life. Clinical symptoms can develop after a latency phase following the injuries and are not specific. Making differential diagnosis based solely on clinical features difficult. CTE can occur with comorbid pathologies (AD, PD, ALS). CTE and aging-related dementias involve similar changes in aggregation prone molecules.
- Risk factor for development of chronic neurodegenerative disorders later in life.
- Prolonged secondary injury cascades after CTE can result in chronic neurodegeneration
- CSF: tau, Aβ42, Αβ42/40 ratio, TDP43, NFL, T-tau, GFAP, STREM2, CSF/serum alburmin ratio
- Plasma: tau, Aβ42, Αβ42/40 ratio, NFL, T-tau, GFAP
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